PDGFRB

PDGFRB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1GQ5, 1H9O, 1SHA, 2L6W, 2PLD, 2PLE, 3MJG
Dynodwyr
Cyfenwau	PDGFRB, CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1, KOGS, PENTT, platelet derived growth factor receptor beta
Dynodwyr allanol	OMIM: 173410 HomoloGene: 1960 GeneCards: PDGFRB
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• vascular endothelial growth factor binding; • kinase activity; • platelet-derived growth factor-activated receptor activity; • transmembrane receptor protein tyrosine kinase activity; • signaling receptor binding; • ATP binding; • protein kinase activity; • platelet-derived growth factor binding; • platelet activating factor receptor activity; • transferase activity; • platelet-derived growth factor receptor binding; • GO:0001948, GO:0016582 protein binding; • protein tyrosine kinase activity; • protein kinase binding; • platelet-derived growth factor beta-receptor activity; • nucleotide binding; • phosphatidylinositol 3-kinase binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • enzyme binding;
Cydrannau o'r gell	• cytoplasm; • bilen; • focal adhesion; • cnewyllyn cell; • apical plasma membrane; • lysosome; • extracellular exosome; • integral component of membrane; • Cellbilen; • lysosomal lumen; • intrinsic component of plasma membrane; • GO:0016023 cytoplasmic vesicle; • cell surface; • Golgi apparatus; • integral component of plasma membrane; • intracellular membrane-bounded organelle; • receptor complex;
Prosesau biolegol	• positive regulation of MAP kinase activity; • positive regulation of phospholipase C activity; • cell migration involved in vasculogenesis; • cardiac myofibril assembly; • positive regulation of smooth muscle cell migration; • protein phosphorylation; • response to lipid; • positive regulation of phosphoprotein phosphatase activity; • positive regulation of reactive oxygen species metabolic process; • metanephric glomerular mesangial cell proliferation involved in metanephros development; • positive regulation of ERK1 and ERK2 cascade; • cell chemotaxis; • inner ear development; • metanephric S-shaped body morphogenesis; • positive regulation of mitotic nuclear division; • platelet-derived growth factor receptor-beta signaling pathway; • positive regulation of collagen biosynthetic process; • phosphatidylinositol metabolic process; • transmembrane receptor protein tyrosine kinase signaling pathway; • cell migration involved in coronary angiogenesis; • metanephric comma-shaped body morphogenesis; • positive regulation of chemotaxis; • positive regulation of DNA biosynthetic process; • protein autophosphorylation; • platelet-derived growth factor receptor signaling pathway; • response to toxic substance; • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; • regulation of actin cytoskeleton organization; • response to retinoic acid; • phosphorylation; • response to hyperoxia; • retina vasculature development in camera-type eye; • metanephric glomerulus morphogenesis; • metanephric mesenchymal cell migration; • wound healing; • cellular response to platelet-derived growth factor stimulus; • negative regulation of apoptotic process; • response to fluid shear stress; • response to estrogen; • chemotaxis; • metanephric mesenchyme development; • response to hydrogen peroxide; • positive regulation of smooth muscle cell proliferation; • response to estradiol; • GO:0007243 intracellular signal transduction; • GO:1904578 response to organic cyclic compound; • smooth muscle cell chemotaxis; • positive regulation of cell migration; • aorta morphogenesis; • MAPK cascade; • positive regulation of phosphatidylinositol 3-kinase activity; • metanephric glomerular capillary formation; • multicellular organism development; • positive regulation of calcium ion import; • glycosaminoglycan biosynthetic process; • positive regulation of cell population proliferation; • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • cell migration; • GO:0072468 signal transduction; • positive regulation of Rho protein signal transduction; • G protein-coupled receptor signaling pathway; • phosphatidylinositol phosphate biosynthetic process; • positive regulation of hepatic stellate cell activation; • positive regulation of fibroblast proliferation; • positive regulation of apoptotic process; • GO:0010260 heneiddio; • male gonad development; • lung growth; • negative regulation of platelet-derived growth factor receptor-beta signaling pathway; • phosphatidylinositol-mediated signaling; • positive regulation of protein kinase B signaling; • hematopoietic progenitor cell differentiation; • positive regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologau
	5159
	n/a
	ENSG00000113721
	n/a
	P09619
	n/a
	NM_002609; NM_001355016; NM_001355017
	n/a
	NP_002600; NP_001341945; NP_001341946
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDGFRB yw PDGFRB a elwir hefyd yn Platelet derived growth factor receptor beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q32.^[2]

[1] "Human PubMed Reference:".

[2] PDGFRB - Cronfa NCBI

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